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Poll Question: Since being on PPIs, has your weight
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Terrapin54
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Quote Terrapin54 Replybullet Posted: 12 Feb 2011 at 6:58pm
Hi Richard,
I've just voted about putting on weight, which makes me happy. Two months ago I was down to 59 kilos (from my 'normal' 72 k) but since I've been on PPI's I have regained my appetite and am now at 63.6 Kgs (hospital scales). I can only put down to PPI's, as before that I had no appetite and ate very sparsely.
RichardBig%20smile
Whereof of one cannot speak, one must remain silent.
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Carolyn
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Quote Carolyn Replybullet Posted: 22 Mar 2011 at 9:20pm
Since I was diagnosed I have lost about 10kg - gone from 73kg to 63kg.   Not sure if it is the PPI (Lanzoprazole) or the fact I stopped drinking rum and coke most evenings and instead have a glass of wine - usually red. I have had heartburn for more years than I can remember (am now 69) and the PPI certainly work for me with no side effects tho I could not take Dr. Reddys Omeprazole. My appetite is good, I exercise regularly and feel good. Just have to forget the Barretts as my next scope is not until next February (2012)I do worry sometimes.
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johnd
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Quote johnd Replybullet Posted: 22 Mar 2011 at 11:20pm
Well after being diagnosed and put on Omeprazole I have to confess that at this stage I could eat anything in any quantity, I think I had better renew the gym membership or else all hell will break loose. It's a strange feeling, on the one hand you have been just told you have something scary, and on the other you have the cure to what I now realise was years of discomfort. You had a problem with Dr Reddy's?
55yo, diagnosed 2011 at 5cm Barrett's, 3cm as at 2013 (?), so far non-D
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RichardT
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Quote RichardT Replybullet Posted: 23 Mar 2011 at 8:19am
> I was diagnosed I have lost about 10kg - gone from 73kg to 63kg. Not sure
> if it is the PPI (Lanzoprazole) or the fact I stopped drinking rum and
> coke most evenings and instead have a glass of wine - usually red.

Acid production is part of an immensely complicated hormonal system. Food ingestion triggers the process and various steps are controlled by acid levels is duodenum and other places. Some of the hormones control bile an pancreatic secretions. Some of the hormones affect the brain causing a feeling of fullness.

Interfering with acid production interferes with the whole system with unpredictable results and it's incredible that more side-effects are not reported. In your case it's quite possible that one side effect is that your appetite is altered. Standard Coke however is full of calories so, unless you were drinking low-calorie Coke, that is probably the answer. But loosing weight is no bad thing surely!

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www.Torrens.org.uk/Med/
www.GreenBottom.org

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Carolyn
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Quote Carolyn Replybullet Posted: 23 Mar 2011 at 9:18am
Hi Johnd:   I was diagnosed about 15 months ago and given Dr. Reddys omeprazole = made me feel really nauseous. The same applied to Dr. Reddys thyroxine. (a cheap version made in India I think). I changed to Lanzoprazole and have had no problems apart from the weight loss. I am 69 and have a 5cm Barretts with LG Dysplasia.
I had scopes every 3 months but now don't need another for a year. They just keep an eye on it here and won't do anything unless it becomes High Grade. I feel well, go to the gym, play a bit of golf and lawn bowls and just have to forget about my problem unless other symptoms show. I was told to eat anything I like in moderation, so life goes on. Have had heartburn for at least 40 years but didn't realise it was doing any damage so just chewed gaviscon if needed.
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chrisrob
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Quote chrisrob Replybullet Posted: 23 Mar 2011 at 11:33am
Peculiarly, when I was first on omeprazole, although usually the pharmacist dispensed a generic version, he occasionally (presumably because of his stock levels?) dispensed the branded "Losec". I found, although according to the patient information sheets they were identical, the Losec was much more effective.
I discussed this with my doctor who said it could be something to do with the size of the granules or the thickness of the enteric capsule but was happy to specify "Losec" on future prescriptions. When I then moved, my new doctor said it was rubbish and only prescribed generic omeprazole which, when it was less effective, she increased the dosage of.

Sorry to have gone off topic a bit.

Carolyn, weight loss (or, indeed, weight gain) are often noticed when diagnosed. But keep an eye on it. If it continues too much or too quickly, speak to your doctor about it. It's one thing to lose weight if you need to but you need to ensure it's under your control.

Your LGD obviously has shown no signs of worsening which is why the consultant feels annual surveillance will be frequent enough for you.
Although NICE guidelines recommend HALO for HGD, it can be used for LGD if the consultant makes a case for it, so if it does worry you, you could ask about going down that route.

All the best

Chris
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jcombs99
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Quote jcombs99 Replybullet Posted: 23 Mar 2011 at 12:08pm
C
    Remember if it turns to HGD (like I HAD)you'll get two options CUT it out or ablate it .Why not beat it like right now and see if you can get in that LGD clinic trial (halo) and be done with it ..How many second opinions did you have?? The doctors say every 6 months scope (EGD) for LGD..
HGD JEFF

" It's better to ablate then wait "

Edited by jcombs99 - 23 Mar 2011 at 1:02pm
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RichardT
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Quote RichardT Replybullet Posted: 23 Mar 2011 at 12:13pm
> the Losec was much more effective.
> I discussed this with my doctor who said it could be something to do with
> the size of the granules or the thickness of the enteric capsule

I've been wondering about the effect of these... The intended action is that the capsule dissolves in the stomach releasing the granules which then take a time to absorb water and burst open. By that time they should be in the gut out of an acid area. However if you try dissolving the capsule, it takes quite a while - it first goes to a sticky mess.

Since I split the 10mG doses in half, I have gotten out of the habit of eating the capsule - all those colourings and other unknown rubbish have never appealed! The granules on their own are likely to pass much quicker through the stomach - especially is it is empty - straight into the intestine, so the whole process is shortened and probably more predictable

There are minor chemical differences between some of the various brands and this could affect the generic effect. However, the half-lives of all the types seen to be short, so the standard dosage is wrong and the effective overdose levels could be causing the differences betwen various brands.
www sites and contact:
www.Torrens.org.uk/Med/
www.GreenBottom.org

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Carolyn
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Quote Carolyn Replybullet Posted: 25 Mar 2011 at 1:29am
Hi to all in the UK and USA.   I live in New Zealand, so Jeff, thanks for the advice, but we don't appear to have any Halo trials going here, and my specialist told me that despite what I have read, ablation IS a big deal and I cannot get it done in New Zealand until it goes HGrade. So I must just continue with my 30mg Lanzoprazole mornings and 300mg ranitidine at night. A retired pathologist I have contact with says I am being treated aggressively and he has seen LGD just dry up and disappear, so I am hoping that is what will happen with mine. My only other problem is sometimes food sticks (like raw apple or carrot) in my throat but the specialist checked me out and says all is OK there. So I just have to put it behind me, but I do read about everyone elses problems on this forum and find it a great way to keep up to date with goings on and reassuring. Thanks everyone.
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johnd
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Quote johnd Replybullet Posted: 25 Mar 2011 at 8:24am
Carolyn

HALO: although this seems like a magic bullet, the gastro's in the UK seem to be not quite sure about it unless its HGD. It would be great if Barrets did just 'go away', it would be a weight off my mind.

I'm on 20 to 30 Omeprazole a day, I take 20 in the evening and sometimes 10 in the morning. I don't know why but I think a smaller dose twice daily is better than once.

Edited by johnd - 25 Mar 2011 at 10:13am
55yo, diagnosed 2011 at 5cm Barrett's, 3cm as at 2013 (?), so far non-D
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