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roganhen
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Quote roganhen Replybullet Topic: Clopidogrel
    Posted: 31 Dec 2018 at 12:09pm
I recently had some ocular migraine problems and just in case a TIA, (mini stroke), was indicated the doctor prescribed the blood thinner Clopidogrel. However I gave up due to stomach upsets including a vomiting attack. I am being encouraged to persevere with the drug but I have to take into account that I have reflux disease and Barrett's.
It seems to me that keeping oesophagitis at bay is not consistent with taking a drug that makes bleeding more likely. I am asking for an input from my gastro consultant but in the meantime would appreciate any information from fellow Barrett's sufferers who have taken aspirin or similar drugs.
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chrisrob
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Quote chrisrob Replybullet Posted: 31 Dec 2018 at 1:12pm
Hi,

It will be interesting to get your gastroenterologist consultant's view on this.

I know the FDA in America recommend the two drugs are not taken concomitantly but I have just searched PubMed for any recent research and come up with this paper: Evaluating the Effect of Six Proton Pump Inhibitors on the Antiplatelet Effects of Clopidogrel which concluded, "These data do not demonstrate a significant interaction between common individual PPIs and clopidogrel in healthy volunteers who respond to clopidogrel alone."
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chrisrob
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Quote chrisrob Replybullet Posted: 07 Jan 2019 at 12:18pm
I passed your query on to one of our consultant gastroenterologist advisers. He was on holiday at the time, but back at work, has sent me this reply:
"There was some press about this 5 or so years ago based on lab studies but these are not translated into clinical practice. I therefore would have no concerns about PPIs reducing the effectiveness of clopidogrel."
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